How to take the course after Tamoxifen?

Tamoxifen (Nolvadex another name, Tamoksimed) – a drug belonging to the group of sex hormones. Available in the form of tablets taken orally. Initially the drug intended for the treatment and prevention of breast cancer in women. Recently, however, I gained a lot of popularity among men bodybuilders. The reason is that most of the steroids taken by athletes, provoke the growth of estrogen, the female sex hormones, which adversely affects the man’s body in the form of so-called feminization. It is manifested in excessive water retention in the body, increasing body fat or even the growth of the breast, do not need any sane man. Tamoxifen is a nonsteroidal anti-estrogenic agents, i.e. it blocks estrogen receptors, so there is no connection “hormone receptor”. This normalizes blood estrogen and testosterone increases. Therefore, bodybuilders and bodybuilders take Tamoxifen to reduce weight while dieting and stimulate muscle growth, as well as for the prevention of adverse events during the course of steroids.

 

Dosing

During the course of tamoxifen steroids used primarily as a prophylactic measure to prevent gynecomastia (breast enlargement), and hormonal disorders. For this purpose, sufficient to take a dosage of 10 mg per day. Dose daily reception will vary in the amount of 10-30mg per day. In rare cases, the dose may be increased to 40mg. More than 40 mg is not recommended to take in order to avoid increased side effects.

In general, a single scheme of reception does not exist. Instructions supplied with the drug, can be thrown away immediately. It is designed for the reception of the funds for other purposes entirely. Individual reception algorithm must be developed specialist. But more often than Tamoxifen is introduced into the course, starting from the second week of reception anaboliticheskih steroids, because the level of estrogen in the blood increases it by the end of the first week of the course.

 

Note that Tamoxifen does not stop completely aromatization steroids, but only blocks the estrogen receptors. Therefore, a sharp increase in blood estrogen may occur after discontinuation of the drug. To avoid this, anti-estrogen drugs are taken in combination with aromatase inhibitors. Read more

The best effect has, in combination with Proviron. Tamoxifen deactivates estrogen receptors and Proviron prevents aromatization of steroids, what “tamoks” does not always cope alone. This is a time-tested and

many professional athletes complex, struggling with an excess of estrogen, which gives the best results.

How to take the course after Tamoxifen?

Why do you need post-cycle therapy (PCT):

  • Restore your own testosterone
  • Save to gain muscle mass
  • Prevent feminization

Avoid testicular atrophy (chorionic gonadotropin is introduced for this purpose in FCT)

To reduce side effects from the course

Post-cycle therapy is necessary no matter how heavy or light the course was. During this period, continue to take Tamoxifen at a dose of 10-20mg per day in combination with Proviron for two – three weeks.

FCT also recommends a course with tamoxifen after 3-4 weeks after a course of steroids anaboliticheskih.

Tamoxifen, however, in no case can not be used after a course of steroids, which included trenbolone or nandrolone.

 

Of the side effects of Tamoxifen are sometimes observed:

 

  • Fervescence
  • dizziness
  • nausea
  • Reduced potency
  • Partial baldness
  • Rashes on the body (acne)
  • Increased fatigue

 

 

 

 

 

However, it is worth noting that the correct approach to the reception of the drug and dosage to 30mg. day side effects are very rare.

 

 

 

Contraindications

 

Before using Tamoxifen is best to check their health, passing a comprehensive examination and consult with a specialist, because there are a number of contraindications.

 

Among them:

 

  • Individual intolerance
  • kidney disease
  • Increased blood clotting
  • diabetes
  • Hormonal disorders
  • liver disease

Considering the contraindications, do not assign themselves this drug alone. Health more awards at competitions and steep shapes of the body.

Also, do not get involved in this drug to women – athletes. It is fraught with hot flashes, excessive body weight, bone pain, irregular menstruation, endometriosis and even infertility.

 

tamoxifen woman

 

Admission results

 

In addition to prevention of estrogen growth and prevent the feminization of, use of the drug reaches several purposes:

 

  1. Power indicators are improving.
  2. Increased relief and muscle hardness.
  3. The reduction of body fat.
  4. The risk of developing atherosclerosis is significantly reduced, as the risk of cardiovascular diseases.
  5. Improves liver function.

Conclusion

Apart from the main effect – blocking estrogen receptors, for which athletes take Tamoxifen, the drug is still a number of properties, beneficial effect on the body. In particular, it increases the level of “good cholesterol” in the blood. This high density cholesterol, which reduces the risk of atherosclerosis and other diseases of the heart and blood vessels. What is especially important for athletes who have a predisposition to such diseases. Besides “tamoks” – a mild drug and it does not load the liver. On the contrary, he helps her, because it has greater activity for blocking estrogen in this organ.

Tamoxifen also stimulates the release into the blood of a large number of gonadotropins, that contributes to the development of your testosterone, which is certainly a plus for the athlete.

Tamoxifen tablets – instructions for use, reviews, descriptions, analogues, the price

Clinico-pharmacological group

Antiestrogen drug with antitumor activity

Pharmachologic effect

Tamoxifen is a nonsteroidal anti-estrogen agent having also weak estrogenic properties. Its action is based on the ability to block estrogen receptors. Tamoxifen, as well as some of its metabolites, estradiol compete for binding sites with cytoplasmic estrogen receptors in breast tissue, uterus, vagina, pituitary gland tumor and with a high content of estrogen receptors. In contrast to estrogen receptor complex receptor complex tamoxifen does not stimulate DNA synthesis in the nucleus and inhibits cell division that leads to tumor regression and cell death.

After oral administration, tamoxifen is well absorbed. Serum Cmax achieved in the range of 4 to 7 h after administration of a single dose. Tamoxifen equilibrium concentration in serum is usually achieved after 3-4 weeks of administration. Relationship to plasma proteins – 99%.

It is metabolized in the liver with the formation of metabolites.

Tamoxifen excretion from the body has a biphasic pattern with an initial T1 / 2 of 7 to 14 hours followed by a slow and a terminal T1 / 2 for 7 days. It provided mainly as conjugates, mainly with faeces and only a small amount excreted in urine. Read more

Dosage

The dosage regimen is generally determined individually depending on the evidence. The daily dose is 20-40 mg. As a standard dose is recommended to take 20 mg of tamoxifen daily for a long time inside. If signs of progression of the disease reception cancel preparation.

Tablets should be taken with liquid, squeezed small amounts of liquid, at once in the morning, or by separating the required dose into two doses, morning and evening.

Overdose

Acute overdose of tamoxifen in humans has not been observed. It is expected that an overdose can cause amplification of the above adverse reactions. There is no specific antidote, treatment should be symptomatic.

Drug interactions

When concomitant administration of tamoxifen and cytotoxic drugs increases the risk of thrombosis.

Antacids, histamine H2-blockers of receptors and other drugs of similar action by raising pH in the stomach can cause premature dissolution and loss of protective effect of enteric tablets. The interval between tamoxifen and these drugs should be 1-2 hours.

There are reports on the strengthening of the anticoagulant effect of drugs tamoxifen coumarin (eg warfarin).

Drugs that reduce the excretion of calcium (eg, thiazide diuretics number) may increase the risk of hypercalcemia.

The combined use of tamoxifen and tegafur can contribute to the development of chronic active hepatitis and cirrhosis.

Concomitant use of tamoxifen with other hormonal drugs (especially estrogensoderjath contraceptives) leads to a weakening of the specific actions of both drugs.

Pregnancy and lactation

Contraindicated.

Tamoxifen can cause ovulation, which increases the risk of pregnancy, in connection with which women who are sexually active, during (and for about 3 months after) treatment with tamoxifen is recommended to use a mechanical or non-hormonal contraceptive.

Side effects

When tamoxifen most common adverse reactions associated with its anti-estrogenic activity, manifested in the form of hot flashes (hot flushes), vaginal bleeding or discharge, itching in the genital area, alopecia, pain in the area of ??the lesion, ossalgia, weight gain.

Less frequently or infrequently observed the following side effects: water retention, anorexia, nausea, vomiting, constipation, fatigue, depression, confusion, headache, dizziness, drowsiness, fever, skin rash, visual disturbances, including corneal changes, cataracts , retinopathy and optic neuritis.

At the beginning of the treatment capacity of local worsening of the disease – an increase in the size of soft tissue structures, sometimes accompanied by severe erythema lesions and surrounding areas – which usually resolves within 2 weeks. It may increase the risk of thrombophlebitis and thromboembolism. Sometimes there may be transient leukopenia and thrombocytopenia, as well as an increase in liver enzymes, rarely accompanied by a severely impaired liver function, such as fatty liver, cholestasis and hepatitis.

In some patients with bone metastases at the beginning of the treatment of hypercalcemia observed.

Tamoxifen causes amenorrhea or irregular menstruation in women in pre-menopausal, as well as the development of reversible cystic ovarian tumors.

With long-term treatment with tamoxifen may experience endometrial changes including hyperplasia, polyps, and in rare cases – endometrial cancer, and the development of uterine fibroids.

Terms and Conditions of storage

List B. In a dry place at temperatures no higher than 25 ° C. Shelf life – 3 years.

testimony

– Estrogen-dependent breast cancer in women (especially in menopause) and male breasts.

The drug can be used to treat ovarian cancer, endometrial cancer, kidney cancer, melanoma, soft tissue sarcomas in the presence of estrogen receptor in the tumor, as well as for the treatment of prostate cancer with resistance to other drugs.

Contraindications

– Pregnancy;

– Lactation;

– Hypersensitivity to tamoxifen and / or any other ingredients of the formulation.

Precautions: renal failure, diabetes, eye diseases (including cataracts), deep vein thrombosis and thromboembolic disease (including history), hyperlipidemia, leukopenia, thrombocytopenia, hypercalcemia, concomitant therapy with indirect anticoagulants.

special instructions

Women taking tamoxifen should undergo regular gynecological examination. When bleeding from the vagina, or vaginal bleeding should stop taking the drug.

In patients with bone metastases periodically during the initial period of treatment should be determined the concentration of calcium in blood serum. In case of apparent violations of tamoxifen should be suspended.

If signs of thrombosis of the lower extremities (leg pain or swelling), pulmonary embolism (shortness of breath), the drug should be discontinued.

During therapy should be periodically monitored blood coagulation indices, blood calcium, blood count (leukocytes and platelets), liver function, blood pressure, inspect an ophthalmologist.

Patients with hyperlipidemia in the treatment necessary to control the concentration of cholesterol and triglycerides in the blood serum.

Effects on ability to drive vehicles and management mechanisms

In the period of treatment should refrain from activities potenialno hazardous activities that require high concentration and psychomotor speed reactions.

Tamoxifen – the best anti-estrogen

Tamoxifen – a medication that has a pronounced anti-estrogen effect. Initially used to treat breast cancer in women. Later widely used in bodybuilding.

 

 

Tamoxifen bodybuilding taken in conjunction with anabolic steroids to prevent the feminization of phenomena. Steroids leads to the fact that the athlete’s body accumulates large amounts of estrogen that may cause gynecomastia, fluid accumulation in the body and the deposition of fat to the subcutaneous tissue. To protect the athlete from such unpleasant phenomena and is intended to tamoxifen. Read more

 

Quite often, athletes combine tamoxifen with Proviron. Thus, tamoxifen enhances fat burning process and increases muscle density.

 

Tamoxifen, instruction manual

Taking tamoxifen regularly for a long time. The dosage of the drug should be chosen based on the individual characteristics of the organism.

 

Tamoxifen daily dose should not exceed 20-40 mg. The optimum dose is 20 mg per day for a long time. The tablet of tamoxifen should be without chewing, swallowing, drinking a small amount of water. This is best done in the morning in one step, or in the morning and in the evening in 2 divided doses.

 

Tamoxifen side effects

Like many drugs have side effects of tamoxifen. The main side effects of tamoxifen treatment experienced by athletes are:

 

  • weight gain
  • hot flushes
  • Baldness and hair loss
  • violation of the process of bone mineralization

Less common: drowsiness, depression, nausea, vomiting, dizziness, fever, anorexia, constipation, skin rash.

 

The emergence of side effects directly related to the anti-estrogenic effect of tamoxifen.

 

Where to buy tamoxifen

Buy tamoxifen securely and anonymously you can online store. Competent consultants, fast delivery, reasonable prices will not leave you indifferent.

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Tamoxifen – full information on the drug Indications for use, how to use, side effects

As an antitumor agent tamoxifen use in breast cancer in postmenopausal women (the body’s condition after menopause is characterized by decreased function of female sex glands and reverse the development of reproductive organs); cancer of the endometrium (uterine lining), as well as anovulatory infertility (infertility caused by lack of egg maturation in the ovaries).

 

Pharmachologic effect:

The mechanism of antiestrogen (preventing the formation or action of female sex hormones) actions of tamoxifen due to its ability to competitively bind to estrogen receptors (cell-wall sections, which interact with female sex hormones) in the target organs and prevent thus the formation estrogenretseptornogo complex with the endogenous ligand (interacting with receptors biological substances produced in the body) – 17-beta-estradiol. see more

 

 

Indications for use:

As an antitumor agent tamoxifen use in breast cancer in postmenopausal women (the body’s condition after menopause is characterized by decreased function of female sex glands and reverse the development of reproductive organs); cancer of the endometrium (uterine lining), as well as anovulatory infertility (infertility caused by lack of egg maturation in the ovaries).

 

 

Mode of application:

Assign inside a pill. When breast cancer take 20-40 mg 1-2 times a day; Endometrial cancer – 30-40 mg 1-2 times a day; with anovulatory infertility by 10 mg 2 times a day for 4 consecutive days, starting on the 2nd day of menstruation. Subsequent four-day cycles can be increased to 20-40 mg dose 2 times a day.

 

 

Side effects:

Possible side effects: gastrointestinal disturbances, dizziness, skin rash, hypercalcemia (increased calcium in the blood), thrombocytopenia (decrease in platelets in the blood). There may be a moderate metrorrhagia (uterine bleeding); in this case, reduce the dose. It was also noted the development of thrombosis (formation of a blood clot in a vessel). At high doses may occur changes in the retina.

 

 

Contraindications:

The drug is contraindicated in pregnancy.

 

 

Product:

Tablets of 0.01 grams (10 mg); 0.02 g (20 mg); 0.04 g (40 mg).

 

 

Storage conditions:

In the dark place at room temperature.

 

 

Synonyms:

Zitazonium, Tamoksifer citrate, Nolvadex, Tamaksin, Tamofen, Tamopleks, Tsitofen, Nolte, Valodeks, Zemid, Tamifen.

 

 

Pharmacological group:

  • Medicines used for the treatment of malignant tumors
  • Sex hormone antagonists
  • antiestrogens

 

 

Attention!

Description “Tamoxifen” drug on this page is a simplified and enlarged version of the official instructions for use. Before purchasing or using the product, you should consult your doctor and see the summary approved by the manufacturer. Read more

Information about the preparation is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide on the appointment of the drug, and to determine the dosage and how to use it.

Tamoxifen bodybuilding – how to take on the FCT after a course?

Tamoxifen is a competitive inhibitor of peripheral estrogen receptor. And if earlier it was believed that the drug does not have the influence of estrogen, but today this view is totally rejected. In fact, the ratio of agonist and antagonist activity equal to 45/55. Tamoxifen is a chemically derived form triphenylethylene. The drug belongs to the group of sex hormones. Initially it was used for the treatment of cancer in women (breast cancer). But, undoubtedly, today Tamoxifen is much more common in sports and bodybuilding in particular.

 

It is no secret that the majority of steroids are exposed flavoring that is converted in to the female sex hormones – estrogens. This can lead to a variety of side effects, which is able to warn svoevremennyypriem Tamoxifen. Unlike other means such exposure, the substance is neither androgen or anabiotic.

 

Action Tamoxifen

 

  • The increase in power performance.
  • Increased hardness and muscle relief.
  • The increase in muscle mass. Tamoxifen is very popular in bodybuilding Argued that without it can not do any one victory in major competitions.
  • The marked anti-estrogen effects. The effect, which made so popular Tamoxifen. The higher dosage of AAC, the greater the need to compensate for estrogenic activity. Tamoxifen or analogues thereof at FCT after heavy courses practically mandatory.
  • The fight against fat.
  • Prevention of feminization.
  • Reducing the risk of developing atherosclerosis, the prevention of cardiovascular disease.
  • Improving liver.

Tamoxifen antiestrogen effects caused by blocking estrogen receptors (rather than the termination of the conversion of testosterone into estrogen, as many think). Preparation only freezes estrogenic activity, and does not prevent it entirely.

 

How to take Tamoxifen after the course

 

How to take Tamoxifen TamoksifenPriem after a course of steroids should be combined with an aromatase inhibitor, the most popular of which is Proviron (it is often used for the reason that it does not inhibit the production of growth hormone and inhibits aromatase, thereby increasing the concentration of anabolic hormones in the blood). Tamoxifen as a primary means of PCT is used in doses of 10 to 20 milligrams daily from the last week of the course and ending the second week of its completion. If Proviron is not accepted, Tamoxifen is included later – at 2 weeks, and ends 2-3 weeks after its cancellation. Read more

 

Please note that the highest levels of estrogen in the body occurs at the end of the first week of the course AAS. As for how to take Tamoxifen bodybuilding on a course of steroids, flavoring has no effect, it is recommended to add it only at the end of the cycle.

 

Side effects

 

The most common side effects of Tamoxifen associated with its pronounced antiestrogenic properties. Exceeding the recommended dose and / or duration of the course can cause female hair loss or total hair loss, flushing intense heat, itching, perineal pain in the bones; men – fever, dizziness, nausea. Because of the delay zhidkostimozhet disrupt the normal functioning of the kidneys. Also, sometimes there are bouts of depression, depression and drowsiness. Excessive intake is fraught with fatigue, constipation, and anorexia. You may experience inflammation of the retina, cataract, partial or complete loss of vision. Tamoxifen is sometimes accompanied by a rash on the skin. Cases of headache, changes in the cornea, unclear consciousness. Liver occur only in case of serious diseases of the body (such as hepatitis).

 

Reviews of Tamoxifen

 

Reviews TamoksifenOchen often expressed about the preparation of the athletes not as Tamoxifen for many years been used in post-menopausal women with estrogen-receptor-positive, and breast cancer patients. As for athletes, they are a marked anti-estrogen effects. Despite the wide range of possible side effects of Tamoxifen reviews indicate that adverse reactions are extremely rare. More info

 

Women athletes talk about the impossibility of use of the drug during pregnancy. In addition, it can prevent the implantation of the egg in the uterine wall. Reviews of tamoxifen on entry-level athletes are rare because amateurs are often bypassed by simple solo AAS courses that do not require FCT.

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