Tamoxifen – the best anti-estrogen

Tamoxifen – a medication that has a pronounced anti-estrogen effect. Initially used to treat breast cancer in women. Later widely used in bodybuilding.

 

 

Tamoxifen bodybuilding taken in conjunction with anabolic steroids to prevent the feminization of phenomena. Steroids leads to the fact that the athlete’s body accumulates large amounts of estrogen that may cause gynecomastia, fluid accumulation in the body and the deposition of fat to the subcutaneous tissue. To protect the athlete from such unpleasant phenomena and is intended to tamoxifen. Read more

 

Quite often, athletes combine tamoxifen with Proviron. Thus, tamoxifen enhances fat burning process and increases muscle density.

 

Tamoxifen, instruction manual

Taking tamoxifen regularly for a long time. The dosage of the drug should be chosen based on the individual characteristics of the organism.

 

Tamoxifen daily dose should not exceed 20-40 mg. The optimum dose is 20 mg per day for a long time. The tablet of tamoxifen should be without chewing, swallowing, drinking a small amount of water. This is best done in the morning in one step, or in the morning and in the evening in 2 divided doses.

 

Tamoxifen side effects

Like many drugs have side effects of tamoxifen. The main side effects of tamoxifen treatment experienced by athletes are:

 

  • weight gain
  • hot flushes
  • Baldness and hair loss
  • violation of the process of bone mineralization

Less common: drowsiness, depression, nausea, vomiting, dizziness, fever, anorexia, constipation, skin rash.

 

The emergence of side effects directly related to the anti-estrogenic effect of tamoxifen.

 

Where to buy tamoxifen

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Tamoxifen – full information on the drug Indications for use, how to use, side effects

As an antitumor agent tamoxifen use in breast cancer in postmenopausal women (the body’s condition after menopause is characterized by decreased function of female sex glands and reverse the development of reproductive organs); cancer of the endometrium (uterine lining), as well as anovulatory infertility (infertility caused by lack of egg maturation in the ovaries).

 

Pharmachologic effect:

The mechanism of antiestrogen (preventing the formation or action of female sex hormones) actions of tamoxifen due to its ability to competitively bind to estrogen receptors (cell-wall sections, which interact with female sex hormones) in the target organs and prevent thus the formation estrogenretseptornogo complex with the endogenous ligand (interacting with receptors biological substances produced in the body) – 17-beta-estradiol. see more

 

 

Indications for use:

As an antitumor agent tamoxifen use in breast cancer in postmenopausal women (the body’s condition after menopause is characterized by decreased function of female sex glands and reverse the development of reproductive organs); cancer of the endometrium (uterine lining), as well as anovulatory infertility (infertility caused by lack of egg maturation in the ovaries).

 

 

Mode of application:

Assign inside a pill. When breast cancer take 20-40 mg 1-2 times a day; Endometrial cancer – 30-40 mg 1-2 times a day; with anovulatory infertility by 10 mg 2 times a day for 4 consecutive days, starting on the 2nd day of menstruation. Subsequent four-day cycles can be increased to 20-40 mg dose 2 times a day.

 

 

Side effects:

Possible side effects: gastrointestinal disturbances, dizziness, skin rash, hypercalcemia (increased calcium in the blood), thrombocytopenia (decrease in platelets in the blood). There may be a moderate metrorrhagia (uterine bleeding); in this case, reduce the dose. It was also noted the development of thrombosis (formation of a blood clot in a vessel). At high doses may occur changes in the retina.

 

 

Contraindications:

The drug is contraindicated in pregnancy.

 

 

Product:

Tablets of 0.01 grams (10 mg); 0.02 g (20 mg); 0.04 g (40 mg).

 

 

Storage conditions:

In the dark place at room temperature.

 

 

Synonyms:

Zitazonium, Tamoksifer citrate, Nolvadex, Tamaksin, Tamofen, Tamopleks, Tsitofen, Nolte, Valodeks, Zemid, Tamifen.

 

 

Pharmacological group:

  • Medicines used for the treatment of malignant tumors
  • Sex hormone antagonists
  • antiestrogens

 

 

Attention!

Description “Tamoxifen” drug on this page is a simplified and enlarged version of the official instructions for use. Before purchasing or using the product, you should consult your doctor and see the summary approved by the manufacturer. Read more

Information about the preparation is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide on the appointment of the drug, and to determine the dosage and how to use it.

Tamoxifen – instructions for use, description and reviews

The active substance group:

Tamoxifen (Tamoxifen), antitumor agent, an anti-estrogen

 

Dosage Form:

tablets, coated tablets

 

Contraindications:

Hypersensitivity, pregnancy, lactation. Eye diseases (including cataracts), hyperlipidemia, leukopenia, thrombocytopenia, hypercalcemia, expressed thrombophlebitis, thromboembolic disease (including history).

 

Dosage and administration:

Usually set individually depending on the evidence.

Inside, breast cancer, kidney – 20-40 mg 1-2 times a day (morning and evening), endometrial – 20-30 mg 1-2 times a day. On course – 2.4-9.6, the treatment is carried out for a long time (until evidence of disease progression), as the effect lasts only against the background of constant use; If necessary, use in combination with radiotherapy and cytostatic therapy.

Tablets should be taken with liquid, squeezed small amounts of liquid in one go in the morning or sharing the required dose into 2 doses, morning and evening.

 

Pharmachologic effect:

The anti-tumor anti-estrogen agent. Competitively inhibits estrogen receptors in the target organs and tumors originating from these bodies. The result is a complex (drug-receptor-cofactor transport), which, after translocation into the nucleus of cells prevents hypertrophy, estrogen dependent regulation. Has antigonadotropnym properties, it inhibits the synthesis of Pg in the tumor tissue. It stops the progression of the tumor process, stimulated by estrogen.

The ability to block estrogen can persist for several weeks after a single dose. Read more

In addition, tamoxifen may cause ovulation in women in its absence, by stimulating the release of GnRH from the hypothalamus, which stimulates the release of pituitary gonadotropins. In men with oligospermia it increases the concentration of LH and FSH, testosterone and estrogen in the blood serum. Tamoxifen and some of its metabolites (N-dezmetiltamoksifen, 4-hydroxy tamoxifen) are potent inhibitors of mixed function oxidases of the cytochrome P450 liver, but the clinical significance of these effects is not defined.

 

Side effects:

Ossalgia, sore lesions, fever; loss of appetite, nausea, vomiting, constipation or diarrhea, and in rare cases – fatty liver, cholestasis, hepatitis; flushing of the skin with a sensation of heat; leukopenia, thrombocytopenia, thrombosis, thromboembolism, thrombophlebitis; skin rash, dry skin, increasing the size of soft tissue structures, sometimes accompanied by severe erythema lesions and surrounding areas (usually goes away within 2 weeks); hypercalcemia, peripheral edema (fluid retention associated with), alopecia, weight gain; depression, headache, dizziness, myasthenia gravis, fatigue, drowsiness, confusion; loss of visual acuity, corneal opacities, cataracts, retinopathy, optic neuritis.

Women – endometrial hyperplasia, a reversible development of cystic tumors, vaginal discharge, metrorrhagia, dysmenorrhea, genital itching, amenorrhea.

The men – reduced potency and / or libido. Peredozirovka. Symptoms: increased side effects.

Treatment: symptomatic. No specific antidote.

 

Special instructions:

Prior to treatment, women should undergo a thorough gynecological (except pregnancy), and physical examination.

Tamoxifen induces ovulation, which increases the risk of pregnancy, so women of childbearing age should use reliable methods of contraception (hormonal) during treatment and for 3 months after treatment.

During the period of treatment is necessary to periodically monitor the performance of blood clotting, Ca2 + concentration in the blood, blood count (leukocytes and platelets), liver function tests, blood pressure, inspect an ophthalmologist – every 3 months, gynecological examination (when a bloody vaginal discharge or vaginal bleeding the drug should be discontinued).

In patients with bone metastases periodically during the initial period of treatment should be to determine the concentration of Ca2 + in the blood serum (in the case of severe hypercalcemia tamoxifen should be suspended). Is ineffective in the treatment of patients with metastatic disease (especially in liver).

If signs of deep vein thrombosis of the lower limbs (leg pain or swelling), thromboembolism, pulmonary artery branches (dyspnea) receiving the drug should be discontinued.

Patients with hyperlipidemia in the treatment process to control the concentration of cholesterol and triglycerides in the blood serum. see more

During the period of treatment must be careful when driving and other lesson. Potentially hazardous activities that require high concentration and speed of psychomotor reactions.

 

Interaction:

  • It enhances the effect of indirect anticoagulants (requires careful monitoring for dose adjustment of anticoagulants).
  • Cytostatics increase the risk of thrombosis.
  • Allopurinol promotes hepatotoxic effects.
  • The combined use of tamoxifen and tegafur can cause chronic active hepatitis and cirrhosis.
  • Concomitant use of tamoxifen with others. Hormonal drugs (contraceptives, especially estrogensoderjath) leads to a weakening of the specific effects of both drugs.
  • Drugs that reduce the excretion of Ca2 + (for example thiazide diuretics number) may increase the risk of hypercalcemia.

Antacids, H2-blockers of histamine receptors and dr.LS reducing gastric acidity, can cause premature dissolution and loss of the protective effect of Valium pills. The interval between tamoxifen and these drugs should be 1-2 hours.

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Tamoxifen bodybuilding: the “pros” and “cons”

Tamoxifen – a rare drug belonging to the group of sex hormones. The original purpose of tamoxifen – providing assistance to the fair sex for cancer – namely, in the treatment of breast cancer.

 

However, the most widespread among men received tamoxifen. At first glance, it may seem incredible, but all will become clear on closer inspection of properties of the drug.

 

Characteristics of tamoxifen

Contents

  • Characteristics of tamoxifen
  • The positive impact on athletes
  • Tamosksifen

Tamoxifen together with anaboliticheskimi steroids can significantly reduce the risk of growth of female hormones in the blood of athletes.

 

Tamoxifen – a drug that differ significantly from providing the same effect of drugs. The main feature of tamoxifen is considered that the medicament is neither anabiotic or androgenic agent.

Bodybuilders and bodybuilders Tamoxifen is recommended as an effective means for weight loss, increase muscle mass and increase power performance.

 

It is logical that in the opinion of bodybuilders tamoxifen impossible without a victory in the competition, if you do not use, of course, doping. Tamoxifen is considered useful among bodybuilders also because it has a pronounced anti-estrogen effect – is a sex hormone.

 

Tamoxifen. The positive impact on athletes

As mentioned above, taking tamoxifen bodybuilding taken together with anaboliticheskimi means. It is caused by the fact that many of the steroids included a large number of flavor components, provoking increasing growth of estrogen in the blood of athletes. The result of this growth is the emergence of the phenomenon of the feminization of athletes – female. More information here

 

This can be expressed in an excessive accumulation of water in the body or enhance the accumulation of fat in the subcutaneous tissue, as well as the phenomenon of gynecomastia (increasing the size of the breast). Perhaps the single and double-sided increase, with the opportunity to return them to their original state only appears when you resort to the surgeon. All this does not need any athlete.

 

Tamoxifen. The positive impact on sportsmenovTamoksifen is the right drug that can prevent the development of all these unpleasant phenomena. Its effect is to block estrogen receptors. As a result, you can not form compounds “estrogen receptor +.”

 

At the same time this is not characteristic of a drug to cause the termination of the conversion of testosterone to estrogen. It turns out that tamoxifen is only struggling with estrogens. However, it is not a proven fact that they did not win a victory over him.

 

Considering all this information specialists bodybuilders often prescribe tamoxifen complex in Proviron. Usually appointed by twenty to thirty milligrams of tamoxifen and no more than fifty milligrams Proviron. Joint reception of these drugs provides a remarkable effect.

 

This combination of drugs bodybuilders can greatly improve your results. Tamoxifen works well during a diet since it helps keeping the fat burning process. Lacking a direct property burn fat, the drug due to its exposure to antiestrogen helps to maintain a reduced level of fat in the body.

 

Tamoxifen should be taken in conjunction with the androgenic steroids or with different variations of testosterone. Athletes who have a tendency to increased accumulation in the body of water, or with a tendency to problems with mammary gland must be used this drug for any steroid treatment for prevention.

 

Since tamoxifen gives excellent results can take many bodybuilders androgenic steroids up until the start of the competition of the day, in combination with a diuretic. This course will give them the opportunity to appear on stage dried and elastic. Those athletes who have fat levels are already low, using tamoxifen get a great chance to significantly increase the density of the muscles.

 

Tamoxifen contributes to the number of units of high density cholesterol (HVP), capable of reducing the risk of atherosclerosis, therefore, it reduces greatly the risk of occurrence of cardiovascular diseases. This feature is very useful for athletes who are often faced with the disease. Another positive aspect is the fact that tamoxifen, a drug being soft, it manifests in the liver greater estrogenic activity. This feature has a positive effect on liver functions and the functioning of the whole organism.

 

However, along with all the advantages, tamoxifen numerous inherent disadvantages, which must be aware of every athlete, without exception, who wants to use this drug.

 

Tamoxifen bodybuilding – application rates and side effects

Tamoxifen has the ability to deal with the excesses of estradiol, which occurs in the body due to the use of flavoring agents during hormone therapy and after its completion. After completing the course AAS’s own production of testosterone decreases significantly, and the body begins to produce instead of testosterone, estradiol, which finally destroys testosterone. But there are ways to combat these phenomena.

Buy tamoxifen

Tamoxifen, as well as Clomid may join estradiol receptors and block them. They block estrogen receptors, but have no effect on the levels of estrogen and the reduction is important not only to suppress the activity of estradiol and lower estrogen levels in the blood. This can be done with the help of anti-estrogen drugs such as Proviron.

Tamoxifen powerful Clomid several times. Therefore, the dosage of tamoxifen – 20-40 mg and Clomid – 50-100 mg. Research Clomid and tamoxifen have shown that is possible to increase the level of testosterone by 42% in 10 days if used tamoxifen 20 mg daily. A Clomid for this would take 150 mg per day.

Tamoxifen

Tenstosteron in the body is produced by exposure to the testes of luteinizing hormone (LH). The PH is, the more testosterone. LH produced by the pituitary gland and its production affects the hypothalamic gonadotropin-releasing hormone (GnRH). The hypothalamus regulates the production of GnRH depending on the level of testosterone and estradiol in the blood. In the production of GnRH it has a negative impact both too low and too high a level of estradiol. read more

Clomid increases LH only in the specified period of 10 minutes, and then it lowers it. Therefore, to use Clomid for more than 10 days is meaningless. Tamoxifen increases the PH 6 consecutive weeks.

In the blood estradiol and testosterone are often in the form of a bound. They are related to a particular protein – SHBG. This means that the bound form of any one of these hormones do not exert their activity. Clomid increases the level of SHBG in the blood, and tamoxifen – no. This is on one hand useful because estradiol is in a bound state, and therefore it is inactive, and on the other hand, also inactive and testosterone, which are already harmful.

The benefits of tamoxifen include the fact that this drug increases the level of high-density cholesterol. The second advantage stems from the fact that tamoxifen – a very mild estrogen, which significantly shows its estrogenic activity in the liver, and this has a positive effect on the entire body.

Clomid We still have one advantage over tamoxifen. Tamoxifen, although only slightly, but still reduce the possibility of developing a body of insulin-like growth factor (IGF-1), and Clomid, which manifests itself as estrogen in the liver are not so active, it has the disadvantage of a lesser degree.

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