Tamoxifen – full information on the drug Indications for use, how to use, side effects

As an antitumor agent tamoxifen use in breast cancer in postmenopausal women (the body’s condition after menopause is characterized by decreased function of female sex glands and reverse the development of reproductive organs); cancer of the endometrium (uterine lining), as well as anovulatory infertility (infertility caused by lack of egg maturation in the ovaries).

 

Pharmachologic effect:

The mechanism of antiestrogen (preventing the formation or action of female sex hormones) actions of tamoxifen due to its ability to competitively bind to estrogen receptors (cell-wall sections, which interact with female sex hormones) in the target organs and prevent thus the formation estrogenretseptornogo complex with the endogenous ligand (interacting with receptors biological substances produced in the body) – 17-beta-estradiol. see more

 

 

Indications for use:

As an antitumor agent tamoxifen use in breast cancer in postmenopausal women (the body’s condition after menopause is characterized by decreased function of female sex glands and reverse the development of reproductive organs); cancer of the endometrium (uterine lining), as well as anovulatory infertility (infertility caused by lack of egg maturation in the ovaries).

 

 

Mode of application:

Assign inside a pill. When breast cancer take 20-40 mg 1-2 times a day; Endometrial cancer – 30-40 mg 1-2 times a day; with anovulatory infertility by 10 mg 2 times a day for 4 consecutive days, starting on the 2nd day of menstruation. Subsequent four-day cycles can be increased to 20-40 mg dose 2 times a day.

 

 

Side effects:

Possible side effects: gastrointestinal disturbances, dizziness, skin rash, hypercalcemia (increased calcium in the blood), thrombocytopenia (decrease in platelets in the blood). There may be a moderate metrorrhagia (uterine bleeding); in this case, reduce the dose. It was also noted the development of thrombosis (formation of a blood clot in a vessel). At high doses may occur changes in the retina.

 

 

Contraindications:

The drug is contraindicated in pregnancy.

 

 

Product:

Tablets of 0.01 grams (10 mg); 0.02 g (20 mg); 0.04 g (40 mg).

 

 

Storage conditions:

In the dark place at room temperature.

 

 

Synonyms:

Zitazonium, Tamoksifer citrate, Nolvadex, Tamaksin, Tamofen, Tamopleks, Tsitofen, Nolte, Valodeks, Zemid, Tamifen.

 

 

Pharmacological group:

  • Medicines used for the treatment of malignant tumors
  • Sex hormone antagonists
  • antiestrogens

 

 

Attention!

Description “Tamoxifen” drug on this page is a simplified and enlarged version of the official instructions for use. Before purchasing or using the product, you should consult your doctor and see the summary approved by the manufacturer. Read more

Information about the preparation is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide on the appointment of the drug, and to determine the dosage and how to use it.

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